the dog island: hitotsu no hana no monogatari
the_dog_island thedogisland THE_DOG_ISLAND_ひとつの花の物語
Literally "THE DOG Island: Story of One Flower". 2007 Wii and PS2 game about a puppy who needs to find medicine for their sick sibling.
Based on Artlist Collection: The DOG. All characters are stylized to match.